Insights into the mechanisms that may clarify obesity as a risk factor for multiple sclerosis
MJD Huitema, GJ Schenk - Current neurology and neuroscience reports, 2018 - Springer
MJD Huitema, GJ Schenk
Current neurology and neuroscience reports, 2018•SpringerAbstract Purpose of Review The proportion to which genetic and environmental factors
contribute to the etiology of multiple sclerosis (MS) is still incompletely understood. An
interesting association between MS etiology and obesity has recently been shown although
the mechanisms underlying this association are still unknown. We propose deregulated gut
microbiota and increased leptin levels as possible mechanisms underlying MS etiology in
obese individuals. Recent Findings Alterations in the human gut microbiota and leptin levels …
contribute to the etiology of multiple sclerosis (MS) is still incompletely understood. An
interesting association between MS etiology and obesity has recently been shown although
the mechanisms underlying this association are still unknown. We propose deregulated gut
microbiota and increased leptin levels as possible mechanisms underlying MS etiology in
obese individuals. Recent Findings Alterations in the human gut microbiota and leptin levels …
Purpose of Review
The proportion to which genetic and environmental factors contribute to the etiology of multiple sclerosis (MS) is still incompletely understood. An interesting association between MS etiology and obesity has recently been shown although the mechanisms underlying this association are still unknown. We propose deregulated gut microbiota and increased leptin levels as possible mechanisms underlying MS etiology in obese individuals.
Recent Findings
Alterations in the human gut microbiota and leptin levels have recently been established as immune modulators in both MS patients and obese individuals. A resemblance between pro-inflammatory bacterial profiles in MS and obese individuals was observed. Furthermore, elevated leptin levels push the immune system towards a more pro-inflammatory state and inhibit the regulatory immune response.
Summary
Deregulated gut microbiota and elevated leptin levels may explain the increased risk of developing MS in obese individuals. Further research to confirm causality is warranted.
Springer
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