Insulin-like growth factor-1 sustains stem cell–mediated renal repair
B Imberti, M Morigi, S Tomasoni, C Rota… - Journal of the …, 2007 - journals.lww.com
In mice with cisplatin-induced acute kidney injury, administration of bone marrow-derived
mesenchymal stem cells (MSC) restores renal tubular structure and improves renal function,
but the underlying mechanism is unclear. Here, we examined the process of kidney cell
repair in co-culture experiments with MSC and cisplatin-injured proximal tubular epithelial
cells (PTEC). Exposure of PTEC to cisplatin markedly reduced cell viability at 4 days, but co-
culture with MSC provided a protective effect by promoting tubular cell proliferation. This …
mesenchymal stem cells (MSC) restores renal tubular structure and improves renal function,
but the underlying mechanism is unclear. Here, we examined the process of kidney cell
repair in co-culture experiments with MSC and cisplatin-injured proximal tubular epithelial
cells (PTEC). Exposure of PTEC to cisplatin markedly reduced cell viability at 4 days, but co-
culture with MSC provided a protective effect by promoting tubular cell proliferation. This …
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