Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression

YS Jeong, D Kim, YS Lee, HJ Kim, JY Han, SS Im… - PloS one, 2011 - journals.plos.org
… In the present study, we aimed to identify ChREBP target genes and their roles on a genome-wide
… parallel sequencing technology (ChIP-seq) and gene expression analysis [12], [13]. …

[PDF][PDF] Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual

YS Jeong, D Kim, YS Lee, HJ Kim, JY Han… - Issue: PLoS ONE …, 2011 - researchgate.net
… In the present study, we aimed to identify ChREBP target genes and their roles on a
genome-wide … parallel sequencing technology (ChIP-seq) and gene expression analysis [12,13]. …

Genome-wide analysis of ChREBP binding sites on male mouse liver and white adipose chromatin

N Poungvarin, B Chang, M Imamura, J Chen… - …, 2015 - academic.oup.com
… structure-function analysis of ChREBP protein revealed an … We explored the ChIP-seq data
using the Integrated Genome … relationships between potential ChREBP target genes and …

ChREBP-mediated regulation of lipid metabolism: involvement of the gut microbiota, liver, and adipose tissue

K Iizuka, K Takao, D Yabe - Frontiers in endocrinology, 2020 - frontiersin.org
… acetate to acetyl CoA by activating its target gene, Acss2, in the liver. … have revealed critical
roles of ChREBP in lipid metabolism. … Genome-wide scanning has also identified a human …

The role of ChREBP in carbohydrate sensing and NAFLD development

M Régnier, T Carbinatti, L Parlati… - Nature Reviews …, 2023 - nature.com
… In agreement, the dual deletion of ChREBP and G6Pase in … Multi-omic analysis also revealed
a positive correlation … which assembles array-based genome-wide association studies, we …

Integrative genomics outlines a biphasic glucose response and a ChREBP-RORγ axis regulating proliferation in β cells

SF Schmidt, JGS Madsen, KØ Frafjord… - Cell reports, 2016 - cell.com
… By integrating motif enrichment within late-regulated enhancers with expression profiles of
… Collectively, our temporal genome-wide analysis of the transcriptional response to glucose …

Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c

JS Bae, AR Oh, HJ Lee, Y Ahn, JY Cha - Biochemical and biophysical …, 2016 - Elsevier
… In fact, genome-wide analysis of ChREBP binding sites revealed that human SREBP-1 was
a direct target of ChREBP in … of ChREBP targets reveals the dual role for ChREBP in glucose-…

Hepatic DGAT2 gene expression is regulated by the synergistic action of ChREBP and SP1 in HepG2 cells

E Shin, JS Bae, JY Han, J Lee, YS Jeong… - Animal Cells and …, 2016 - Taylor & Francis
… one of the targets of ChREBP using chromatin immunoprecipitation-… Using genome-wide
analysis of ChREBP binding sites in … In this study, we have revealed the direct binding of SP1 to …

Chrebp regulates itself and metabolic genes implicated in lipid accumulation in β–cell line

C Sae-Lee, K Moolsuwan, L Chan, N Poungvarin - PLoS One, 2016 - journals.plos.org
… In order to get a more comprehensive picture on ChREBP-… ChREBP target gene [41], we
clearly showed that ChREBP … Our study demonstrates that functional ChoRE sequence of rat …

Lxrα regulates chrebpα transactivity in a target gene-specific manner through an agonist-modulated lbd-lid interaction

Q Fan, RC Nørgaard, I Grytten, CM Ness, C Lucas… - Cells, 2020 - mdpi.com
… By functioning as a ‘metabolic sensor,’ LXR can integrate … seemingly high genome-wide
co-occupancy of ChREBP and … These data reveal that ligand-activated LXRα plays distinct …