Integrating in silico models to enhance predictivity for developmental toxicity
M Marzo, S Kulkarni, A Manganaro, A Roncaglioni… - Toxicology, 2016 - Elsevier
Application of in silico models to predict developmental toxicity has demonstrated limited
success particularly when employed as a single source of information. It is acknowledged
that modelling the complex outcomes related to this endpoint is a challenge; however, such
models have been developed and reported in the literature. The current study explored the
possibility of integrating the selected public domain models (CAESAR, SARpy and P&G
model) with the selected commercial modelling suites (Multicase, Leadscope and Derek …
success particularly when employed as a single source of information. It is acknowledged
that modelling the complex outcomes related to this endpoint is a challenge; however, such
models have been developed and reported in the literature. The current study explored the
possibility of integrating the selected public domain models (CAESAR, SARpy and P&G
model) with the selected commercial modelling suites (Multicase, Leadscope and Derek …
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