Painful diabetic neuropathy (PDN) is one of the most common and intractable complications
of diabetes. PDN is characterized by small-fiber degeneration and neuropathic pain.
Uncovering the mechanisms underlying neurodegeneration in PDN remains a major
challenge to finding effective and disease-modifying therapy. Keratinocytes are closely
juxtaposed to cutaneous nerve terminals potentially enabling communication between
keratinocytes and cutaneous afferents. The aim of this study is to explore mechanisms by …