Interleukin 10 promoter region polymorphisms in inflammatory bowel disease in Tunisian population
R Marrakchi, A Moussa, S Ouerhani, K Bougatef… - Inflammation …, 2009 - Springer
R Marrakchi, A Moussa, S Ouerhani, K Bougatef, R Bouhaha, Y Messai, K Rouissi…
Inflammation Research, 2009•SpringerObjective: To test whether IL-10 promoter region polymorphisms are associated with
susceptibility to inflammatory bowel disease, we examined the contribution of interleukin-10
(IL-10) gene polymorphisms to Crohn's disease (CD) and Ulcerative colitis disease (UC)
occurrence and also to CD phenotype. Materiels and Methods: SNPs at positions-627 (C>
A) and− 1117 (G> A) in the IL-10 promoter were determined in a sample of 105 Tunisian
patients with IBD (75 CD and 30 UC) and 90 matched healthy controls. Results: The 627 CA …
susceptibility to inflammatory bowel disease, we examined the contribution of interleukin-10
(IL-10) gene polymorphisms to Crohn's disease (CD) and Ulcerative colitis disease (UC)
occurrence and also to CD phenotype. Materiels and Methods: SNPs at positions-627 (C>
A) and− 1117 (G> A) in the IL-10 promoter were determined in a sample of 105 Tunisian
patients with IBD (75 CD and 30 UC) and 90 matched healthy controls. Results: The 627 CA …
Objective
To test whether IL-10 promoter region polymorphisms are associated with susceptibility to inflammatory bowel disease, we examined the contribution of interleukin- 10 (IL-10) gene polymorphisms to Crohn’s disease (CD) and Ulcerative colitis disease (UC) occurrence and also to CD phenotype.
Materiels and Methods
SNPs at positions -627 (C > A) and −1117 (G > A) in the IL-10 promoter were determined in a sample of 105 Tunisian patients with IBD (75 CD and 30 UC) and 90 matched healthy controls.
Results
The 627 CA genotype is associated with ileal location (p = 0.015) and with stricturing (p = 510-3) and penetrating (p = 310-3) presentation of CD. An additive effect between IL10 variants and CARD15 3020 insC mutation (p = 0,006) on severe forms of CD was shown.
Conclusions
In Tunisian population, the 3020insC insertion in NOD2/CARD15 gene is a marker of susceptibility to CD, while the A allele at position -627 in the IL-10 promoter increases the risk of CD ileal location and severe disease presentation. A genetic epistasis between IL-10 gene polymorphisms and CARD15/NOD2 gene mutation was suggested.
Springer
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