Interleukin-1β gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection
Y Wang, N Kato, Y Hoshida, H Yoshida, H Taniguchi… - Hepatology, 2003 - journals.lww.com
Hepatitis C virus (HCV) infection is a major risk factor for developing hepatocellular
carcinoma (HCC), a life-threatening sequel. However, the factors that affect disease
progression to HCC have not been thoroughly elucidated. Genetic polymorphisms in
proinflammatory cytokines, the interleukin 1 (IL-1) family (IL-1β and IL-1ra) and tumor
necrosis factor-α (TNF-α), were studied in 274 Japanese patients with chronic HCV infection
and 55 healthy individuals using standard polymerase chain reaction-based genotyping …
carcinoma (HCC), a life-threatening sequel. However, the factors that affect disease
progression to HCC have not been thoroughly elucidated. Genetic polymorphisms in
proinflammatory cytokines, the interleukin 1 (IL-1) family (IL-1β and IL-1ra) and tumor
necrosis factor-α (TNF-α), were studied in 274 Japanese patients with chronic HCV infection
and 55 healthy individuals using standard polymerase chain reaction-based genotyping …
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