Interleukin-10 (IL-10) polymorphisms are associated with IL-10 production and clinical malaria in young children

G Zhang, MN Manaca, M McNamara-Smith… - Infection and …, 2012 - Am Soc Microbiol
The role of interleukin-10 (IL-10) in malaria remains poorly characterized. The aims of this
study were to investigate (i) whether genetic variants of the IL-10 gene influence IL-10
production and (ii) whether IL-10 production as well as the genotypes and haplotypes of the
IL-10 gene in young children and their mothers are associated with the incidence of clinical
malaria in young children. We genotyped three IL-10 single nucleotide polymorphisms in
240 children and their mothers from a longitudinal prospective cohort and assessed the IL …

Interleukin-10 (IL-10) polymorphisms are associated with IL-10 production and clinical malaria in young children.

ZGC Zhang GuiCheng, MN Manaca… - 2012 - cabidigitallibrary.org
The role of interleukin-10 (IL-10) in malaria remains poorly characterized. The aims of this
study were to investigate (i) whether genetic variants of the IL-10 gene influence IL-10
production and (ii) whether IL-10 production as well as the genotypes and haplotypes of the
IL-10 gene in young children and their mothers are associated with the incidence of clinical
malaria in young children. We genotyped three IL-10 single nucleotide polymorphisms in
240 children and their mothers from a longitudinal prospective cohort and assessed the IL …
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