Irrigation and instrumentation of root canal alone cannot eliminate micro organisms.[...] along with the irrigation and instrumentation of root canal, intra canal medicament is required to disinfect and reduce the bacterial loading5. Most of the microbial flora is suppressed by non specific antibiotic but there are higher chances of multiplication of residual virulent micro-organisms in root canal.[...] it is essential to use combination of antibiotics to act against all endodontic pathogens and to prevent resistance. The ideal or optimum vehicle for delivery of antibiotics in root canal should have ability to facilitate better diffusion of medicament through dentinal tubules and anatomical aberrations like fins, isthmuses and blocked canals.[...] diffusion of antibiotic into cementum and periradicular tissue may be advantageous. used Propylene glycol and macrogol was used by Hoshino et al for delivery of triple antibiotic paste26. Combination of ciprofloxacin/polyethylene glycol was most effective in reducing bacterial count and yeasts.[...] delivery of the drug with ideal vehicle into root canal reduces the bacterial loads in the infected root canal.