Intracellular proton-mediated activation of TRPV3 channels accounts for the exfoliation effect of α-hydroxyl acids on keratinocytes
Background: Little is known about how α-hydroxyl acids (AHAs) widely cause exfoliation to
expose fresh skin cells. Results: Transient receptor potential vanilloid 3 (TRPV3) channel in
keratinocytes is potently activated by intracellular acidification induced by glycolic acid.
Conclusion: TRPV3-mediated proton-sensing and cell death in keratinocytes may serve as a
molecular basis for the cosmetic use of AHAs. Significance: We describe a novel mechanism
by which TRPV3 is activated by intracellular protons.
expose fresh skin cells. Results: Transient receptor potential vanilloid 3 (TRPV3) channel in
keratinocytes is potently activated by intracellular acidification induced by glycolic acid.
Conclusion: TRPV3-mediated proton-sensing and cell death in keratinocytes may serve as a
molecular basis for the cosmetic use of AHAs. Significance: We describe a novel mechanism
by which TRPV3 is activated by intracellular protons.
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