Intraperitoneal delivery of human natural killer cells for treatment of ovarian cancer in a mouse xenograft model
MA Geller, DA Knorr, DA Hermanson, L Pribyl… - Cytotherapy, 2013 - Elsevier
Background aims There is an urgent need for novel therapeutic strategies for relapsed
ovarian cancer. Dramatic clinical anti-tumor effects have been observed with interleukin (IL)-
2 activated natural killer (NK) cells; however, intravenous delivery of NK cells in patients with
ovarian cancer has not been successful in ameliorating disease. We investigated in vivo
engraftment of intraperitoneally (IP) delivered NK cells in an ovarian cancer xenograft model
to determine if delivery mode can affect tumor cell killing and circumvent lack of NK cell …
ovarian cancer. Dramatic clinical anti-tumor effects have been observed with interleukin (IL)-
2 activated natural killer (NK) cells; however, intravenous delivery of NK cells in patients with
ovarian cancer has not been successful in ameliorating disease. We investigated in vivo
engraftment of intraperitoneally (IP) delivered NK cells in an ovarian cancer xenograft model
to determine if delivery mode can affect tumor cell killing and circumvent lack of NK cell …
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