BACKGROUND AND PURPOSE: Intrathecal contrast-enhanced glymphatic MR imaging has
shown promise in assessing glymphatic function in patients with dementia. The purpose of
this study was to determine the safety profile and feasibility of this new MR imaging
technique. MATERIALS AND METHODS: A prospective safety and feasibility study was
performed in 100 consecutive patients (58 women and 42 men, 51±19 years of age)
undergoing glymphatic MR imaging from September 2015 to August 2018. Short-and long …

Neurodegenerative diseases are typically characterized by toxic deposits of proteins from
brain metabolism. As such, amyloid-beta plaques and tau neurofibrillary tangles are
hallmark lesions of Alzheimer disease (AD). 1 Several amyloid-beta isoforms and tau protein
seem to be excreted from brain along paravascular routes in free communication with the
subarachnoid compartment and CSF. Recent studies have demonstrated that brain
molecular clearance is highly dependent on CSF clearance to meningeal lymphatic vessels …