IMPLICATIONS: Remifentanil infusion in normal volunteers acutely reduces hypersensitivity
induced by capsaicin, but after cessation of remifentanil infusion, hypersensitivity increases
beyond baseline, consistent with growing animal and human literature suggesting that acute
exposure to opioids, such as during surgery, can exacerbate subsequent pain. Animal
studies of opioid analgesia suggest that hyperalgesia to noxious mechanical or heat
stimulation may develop even after a single exposure to potent opioids (1, 2). Evidence in …

Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin-induced
hyperalgesia | CiNii Research … Intravenous remifentanil produces withdrawal
hyperalgesia in volunteers with capsaicin-induced hyperalgesia …