Inverse probability of treatment weighting and confounder missingness in electronic health record-based analyses: a comparison of approaches using plasmode …
… We investigated performance of multiple imputation and propensity score (PS) calibration
when conducting inverse probability of treatment weights (IPTW)-based comparative
effectiveness research using EHR data with missingness in confounder variables and
outcome misclassification. Our motivating example … Our results support multiple
imputation and PS calibration approaches to missingness in missing completely at random
or missing at random confounder variables in EHR-based IPTW comparative effectiveness …
when conducting inverse probability of treatment weights (IPTW)-based comparative
effectiveness research using EHR data with missingness in confounder variables and
outcome misclassification. Our motivating example … Our results support multiple
imputation and PS calibration approaches to missingness in missing completely at random
or missing at random confounder variables in EHR-based IPTW comparative effectiveness …
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