Cell-to-cell communication plays important roles in development and in tissue
morphogenesis. Gap junctional intercellular communication (GJIC) has been implicated in
embryonic development of various tissues and provides a pathway to exchange ions,
secondary messengers, and metabolites through the intercellular gap junction channels.
Although GJIC is absent in adult skeletal muscles, the formation of skeletal muscles involves
a sequence of complex events including cell-cell interaction processes where myogenic …