[HTML][HTML] Involvement of pro-and antinociceptive factors in minocycline analgesia in rat neuropathic pain model
E Rojewska, K Popiolek-Barczyk, AM Jurga… - Journal of …, 2014 - Elsevier
In neuropathic pain the repeated minocycline treatment inhibited the mRNA and protein
expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline
diminished the pronociceptive (IL-6, IL-18), but not antinociceptive (IL-1alpha, IL-4, IL-10)
cytokines at the spinal cord level. In vitro primary cell culture studies have shown that MMP-
9, TIMP-1, IL-1beta, IL-1alpha, IL-6, IL-10, and IL-18 are of microglial origin. Minocycline
reduces the production of pronociceptive factors, resulting in a more potent antinociceptive …
expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline
diminished the pronociceptive (IL-6, IL-18), but not antinociceptive (IL-1alpha, IL-4, IL-10)
cytokines at the spinal cord level. In vitro primary cell culture studies have shown that MMP-
9, TIMP-1, IL-1beta, IL-1alpha, IL-6, IL-10, and IL-18 are of microglial origin. Minocycline
reduces the production of pronociceptive factors, resulting in a more potent antinociceptive …
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