Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides
Y Takahashi, R Yoshii, T Sato, N Chida - Organic letters, 2018 - ACS Publications
Y Takahashi, R Yoshii, T Sato, N Chida
Organic letters, 2018•ACS PublicationsAn iridium-catalyzed reductive nucleophilic addition to secondary amides is reported. After
the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the
Mannich reaction, allylation, and [3+ 2]-cycloaddition. The method shows high
chemoselectivity in the presence of other functional groups such as methyl ester.
the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the
Mannich reaction, allylation, and [3+ 2]-cycloaddition. The method shows high
chemoselectivity in the presence of other functional groups such as methyl ester.
An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported. After the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the Mannich reaction, allylation, and [3 + 2]-cycloaddition. The method shows high chemoselectivity in the presence of other functional groups such as methyl ester.
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