Islet Gene View—a tool to facilitate islet research
… -wide genetic variation data (GWAS) from human pancreatic islets, as … tool, the Islet Gene
View (IGW), which will allow rapid and robust overview of data, as well as “look-up” of genes of …
View (IGW), which will allow rapid and robust overview of data, as well as “look-up” of genes of …
Every islet matters: improving the impact of human islet research
… Islet Core (AIC), which facilitates … islet gene expression data across multiple cohorts in the
context of other tissues and provides details of islet expression quantitative loci for each gene. …
context of other tissues and provides details of islet expression quantitative loci for each gene. …
Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes
… that islet enhancer hubs are connected with key islet gene … this study (see also Supplementary
Table 4). NT, not tested. c, … This resource can therefore assist efforts to understand the …
Table 4). NT, not tested. c, … This resource can therefore assist efforts to understand the …
[HTML][HTML] The pancreatic islet regulome browser
L Mularoni, M Ramos-Rodríguez, L Pasquali - Frontiers in Genetics, 2017 - frontiersin.org
… We believe that such tool will facilitate the access to pancreatic islet … Islet-specific genes are
shown in dark gray. … different fields of research including pancreatic islet regulatory genomics…
shown in dark gray. … different fields of research including pancreatic islet regulatory genomics…
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
… We procured the islet samples used in this study from the Integrated Islet Distribution … We
scanned each haplotype using the find individual motif occurrences (FIMO) tool with PWMs …
scanned each haplotype using the find individual motif occurrences (FIMO) tool with PWMs …
From genetic association to molecular mechanisms for islet-cell dysfunction in type 2 diabetes
KK Mattis, AL Gloyn - Journal of molecular biology, 2020 - Elsevier
… The study of these T2D risk variants in normoglycemic individuals has revealed that a … on
the genetic basis of T2D focusing on approaches, which have facilitated the identification of …
the genetic basis of T2D focusing on approaches, which have facilitated the identification of …
[HTML][HTML] Recent developments in islet biology: a review with patient perspectives
L Basu, V Bhagat, MEA Ching… - Canadian Journal of …, 2023 - Elsevier
… and AZD1656, were developed to promote insulin secretion in the … the genetic, and molecular
alterations involved in islet … omics tools to better understand the molecular causes of islet …
alterations involved in islet … omics tools to better understand the molecular causes of islet …
Identification of novel type 1 diabetes candidate genes by integrating genome-wide association data, protein-protein interactions, and human pancreatic islet gene …
R Bergholdt, C Brorsson, A Palleja, LA Berchtold… - Diabetes, 2012 - Am Diabetes Assoc
… The hypothesis behind this study was that integration of GWAS data with protein-protein
interactions and gene expression would facilitate a systems-based understanding of type 1 …
interactions and gene expression would facilitate a systems-based understanding of type 1 …
[HTML][HTML] Recent progress in pancreatic islet cell therapy
EZ Sim, N Shiraki, S Kume - Inflammation and Regeneration, 2021 - Springer
… These PSC-derived pancreatic islet cells are a potential tool … for differentiation cues,
facilitating the future development of … and gene editing can be combined in the study of disease …
facilitating the future development of … and gene editing can be combined in the study of disease …
[HTML][HTML] Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program
SN Shapira, A Naji, MA Atkinson, AC Powers… - Cell metabolism, 2022 - cell.com
… to identify genetic variation associated with a change in gene … (acQTLs), facilitating a unique
ability to map gene regulatory … tools distributed through PANC-DB to enable researchers to …
ability to map gene regulatory … tools distributed through PANC-DB to enable researchers to …