Objective To validate the ability of serum kisspeptin-54 to discriminate between first-trimester
viable pregnancies and miscarriages. Design Case-control study. Setting Academic medical
centers. Patient (s) Women with confirmed viable intrauterine pregnancy (IUP) at estimated
gestational age 6–10 weeks (n= 20), women with confirmed miscarriage (spontaneous
abortion [SAB]) at estimated gestational age 6–10 weeks (n= 20), and nonpregnant women
(n= 19). Intervention (s) Collection of serum samples from women with confirmed IUP, SAB …

… CONCLUSIONS: Plasma levels of kisspeptin have been suggested as a biomarker for
miscarriage. This study demonstrates kisspeptin assay stability in serum. In early pregnancy,
kisspeptin levels increase with gestational age but are significantly lower in women with
miscarriage. …