LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice
D Muller, BH Koller, JL Whitton, KE LaPan, KK Brigman… - Science, 1992 - science.org
D Muller, BH Koller, JL Whitton, KE LaPan, KK Brigman, JA Frelinger
Science, 1992•science.orgIntracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes
meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-
restricted cytotoxic T lymphocytes (CTLs). β2-Microglobulin-deficient mice (β2M-/-) do not
express functional MHC class I proteins and do not produce significant numbers of CD8+ T
cells. When β2M-/-mice were infected with LCMV, many died from LCMV disease and
produced a specific response to LCMV mediated by CD4+ CTLs that were class II-restricted …
meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-
restricted cytotoxic T lymphocytes (CTLs). β2-Microglobulin-deficient mice (β2M-/-) do not
express functional MHC class I proteins and do not produce significant numbers of CD8+ T
cells. When β2M-/-mice were infected with LCMV, many died from LCMV disease and
produced a specific response to LCMV mediated by CD4+ CTLs that were class II-restricted …
Intracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs). β2-Microglobulin-deficient mice (β2M-/-) do not express functional MHC class I proteins and do not produce significant numbers of CD8+ T cells. When β2M-/- mice were infected with LCMV, many died from LCMV disease and produced a specific response to LCMV mediated by CD4+ CTLs that were class II-restricted. In these mice, CD4+ CTLs may compensate for the lack of CD8+ CTLs.
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