LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice
… Pinch2 globally in mice. Through … mouse models, we established critical roles for Pinch1/2
and a functional redundancy of both factors in the control of chondrogenesis and bone mass …
and a functional redundancy of both factors in the control of chondrogenesis and bone mass …
[HTML][HTML] Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice
Y Wang, Q Yan, Y Zhao, X Liu, S Lin, P Zhang, L Ma… - JCI insight, 2019 - ncbi.nlm.nih.gov
… They are 5 LIM domain–containing proteins that play important … — regulates chondrogenesis
and early skeletal development … mutant mice, we establish a critical role of Pinch1/2 and a …
and early skeletal development … mutant mice, we establish a critical role of Pinch1/2 and a …
Brief research report: Effects of Pinch deficiency on cartilage homeostasis in adult mice
… Pinch1 and Pinch2 are LIM domain-containing proteins with … previous study with mice lacking
Pinch1/2 in adult cartilage (… Pinch proteins are essential for chondrogenesis and cartilage …
Pinch1/2 in adult cartilage (… Pinch proteins are essential for chondrogenesis and cartilage …
[HTML][HTML] Loss of pinch proteins causes severe degenerative disc disease-like lesions in mice
… Pinch proteins are a family of LIM domain-containing proteins … We have demonstrated that
Pinch proteins control bone, cartilage, … We provide convincing evidence that loss of Pinch1/2 …
Pinch proteins control bone, cartilage, … We provide convincing evidence that loss of Pinch1/2 …
The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway
… that bone marrow stromal cells (BMSCs) lacking Pinch1/2 … from control and dKO mice to
investigate the changes of bone … impairs both chondrogenesis and osteogenesis in mice [22]. …
investigate the changes of bone … impairs both chondrogenesis and osteogenesis in mice [22]. …
Pinch loss ameliorates obesity, glucose intolerance, and fatty liver by modulating adipocyte apoptosis in mice
… complex and contain five LIM domains, which mediate critical protein-protein interactions.
For … of Pinch1/2 in osteocytes regulated bone mass and bone mineral density through indirect …
For … of Pinch1/2 in osteocytes regulated bone mass and bone mineral density through indirect …
[HTML][HTML] Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in mice
X Wu, M Qu, W Gong, C Zhou, Y Lai, G Xiao - Journal of Orthopaedic …, 2022 - Elsevier
… demonstrate that the focal adhesion protein Kindlin-2 exerts … cells controls chondrogenesis
and bone mass. We may define … regulation of skeletal development and postnatal bone mass …
and bone mass. We may define … regulation of skeletal development and postnatal bone mass …
Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality
… PINCH proteins are 5 LIM domain–only adaptor proteins that … , we generated several mouse
lines in which PINCH1 and … samples from CDKO and control mice at postnatal day 10, when …
lines in which PINCH1 and … samples from CDKO and control mice at postnatal day 10, when …
Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
… In bone tissue, Kindlin-2 regulates chondrogenesis 41 , … the focal adhesion protein,
Kindlin-2, in the regulation of force … bone mass and stimulates bone formation in control mice. …
Kindlin-2, in the regulation of force … bone mass and stimulates bone formation in control mice. …
[HTML][HTML] Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice
… β1 integrin in the control of bone mass and mediation of bone … in bone of transgenic mice
lacking other FA proteins Pinch1/2 … bone resorption, which is similar to the results from Pinch1/2 …
lacking other FA proteins Pinch1/2 … bone resorption, which is similar to the results from Pinch1/2 …