Lactate spares glucose as a metabolic fuel in neurons and astrocytes from primary culture
A Tabernero, C Vicario, JM Medina - Neuroscience research, 1996 - Elsevier
The effect of lactate on glucose metabolism in neurons and astrocytes from primary culture
has been studied. The rates of glucose metabolism through the pentose-phosphate shunt,
the pyruvate dehydrogenase-catalyzed reaction, the tricarboxylic acid cycle, the total
lipogenesis and the synthesis of glycerol-borne lipids in astrocytes were 2–3 fold higher
than in neurons. However, the rate of glucose incorporation into sterols and esterified fatty
acids was similar in both types of cells. Total glucose utilization was inhibited by lactate to …
has been studied. The rates of glucose metabolism through the pentose-phosphate shunt,
the pyruvate dehydrogenase-catalyzed reaction, the tricarboxylic acid cycle, the total
lipogenesis and the synthesis of glycerol-borne lipids in astrocytes were 2–3 fold higher
than in neurons. However, the rate of glucose incorporation into sterols and esterified fatty
acids was similar in both types of cells. Total glucose utilization was inhibited by lactate to …
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