Laparoscopic probe for sentinel lymph node harvesting using magnetic nanoparticles
MM van de Loosdrecht, L Molenaar… - IEEE Transactions …, 2021 - ieeexplore.ieee.org
MM van de Loosdrecht, L Molenaar, EJG Krooshoop, B ten Haken, WJHJ Meijerink, L Alic…
IEEE Transactions on Biomedical Engineering, 2021•ieeexplore.ieee.orgObjective: Sentinel lymph node harvesting is an essential step in the surgical treatment of a
growing number of malignancies. Various techniques are available to facilitate this purpose.
The present study reports a new laparoscopic technique for lymph node harvesting using
magnetic nanoparticles containing a superparamagnetic iron-oxide core and dextran
coating. This study assesses the clinical relevance of the prototype and provides input for
further technological development on the way to clinical implementation. Methods: A …
growing number of malignancies. Various techniques are available to facilitate this purpose.
The present study reports a new laparoscopic technique for lymph node harvesting using
magnetic nanoparticles containing a superparamagnetic iron-oxide core and dextran
coating. This study assesses the clinical relevance of the prototype and provides input for
further technological development on the way to clinical implementation. Methods: A …
Objective
Sentinel lymph node harvesting is an essential step in the surgical treatment of a growing number of malignancies. Various techniques are available to facilitate this purpose. The present study reports a new laparoscopic technique for lymph node harvesting using magnetic nanoparticles containing a superparamagnetic iron-oxide core and dextran coating. This study assesses the clinical relevance of the prototype and provides input for further technological development on the way to clinical implementation.
Methods
A laparoscopic differential magnetometer prototype was built, utilizing a nonlinear detection principle (differential magnetometry) for magnetic identification of lymph nodes. The iron content sensitivity, depth & spatial sensitivity, and angular sensitivity were analyzed to investigate clinical options.
Results
The minimum detectable amount of iron was 9.8 μg at a distance of 1 mm. The detection depth was 5, 8, and 10 mm for samples containing 126, 252, and 504 μg iron, respectively. The maximum lateral detection distance was 5, 7, and 8 mm for samples containing 126, 252, and 504 μg iron, respectively. A sample containing 504 μg iron was detectable at all angulations assessed (0°, 30°, 60° and 90°).
Conclusion
The laparoscopic differential magnetometer demonstrates promising results for further investigation and development towards laparoscopic lymph node harvesting using magnetic nanoparticles.
Significance
The laparoscopic differential magnetometer facilitates a novel method for sentinel lymph node harvesting, which helps to determine prognosis and treatment of cancer patients.
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