Leptin transcriptionally enhances peptide transporter (hPepT1) expression and activity via the cAMP-response element-binding protein and Cdx2 transcription factors
PepT1 is an intestinal epithelial apical membrane transporter that is expressed in the small
intestine, with little or no expression in the normal colon. However, we previously
demonstrated that colonic PepT1 may be expressed during chronic inflammation. To begin
elucidating inflammatory hPepT1 signaling, we herein investigated the long term leptin
treatments, on PepT1 expression and activity in Caco2-BBE cells, and began to reveal the
involved signaling pathways. We successfully cloned the 723-bp hPepT1 promoter region …
intestine, with little or no expression in the normal colon. However, we previously
demonstrated that colonic PepT1 may be expressed during chronic inflammation. To begin
elucidating inflammatory hPepT1 signaling, we herein investigated the long term leptin
treatments, on PepT1 expression and activity in Caco2-BBE cells, and began to reveal the
involved signaling pathways. We successfully cloned the 723-bp hPepT1 promoter region …
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