Member countries of SAARC (South Asian Association for Regional Cooperation) and ASEAN (Association of South East Asian Nations) have long history of LIS (Library and Information Science) education and research. This study compares LIS research output in member countries of these two associations, using LISA (Library and Information Science Abstracts) data. The study focuses on the pattern of literature growth, core journals, authorship pattern and research trends. Finds that SAARC countries are ahead of ASEAN members. India is leading in LIS among SAARC countries and Singapore among ASEAN countries. As per LISA, both groups have marginal contribution in international journals and therefore, core journals are of Asian origin only. The results of study call for more collaboration among the member countries of SAARC and ASEAN. It also identifies the need for formulation and implementation of information policy similar to that of Singapore among member nations of both the regional associations.