Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma
MA Comunale, L Rodemich-Betesh, J Hafner, M Wang… - PloS one, 2010 - journals.plos.org
Background We previously reported increased levels of protein-linked fucosylation with the
development of liver cancer and identified many of the proteins containing the altered glycan
structures. One such protein is alpha-1-antitrypsin (A1AT). To advance these studies, we
performed N-linked glycan analysis on the five major isoforms of A1AT and completed a
comprehensive study of the glycosylation of A1AT found in healthy controls, patients with
hepatitis C-(HCV) induced liver cirrhosis, and in patients infected with HCV with a diagnosis …
development of liver cancer and identified many of the proteins containing the altered glycan
structures. One such protein is alpha-1-antitrypsin (A1AT). To advance these studies, we
performed N-linked glycan analysis on the five major isoforms of A1AT and completed a
comprehensive study of the glycosylation of A1AT found in healthy controls, patients with
hepatitis C-(HCV) induced liver cirrhosis, and in patients infected with HCV with a diagnosis …
[PDF][PDF] Linkage Specific Fucosylation of Alpha-1-Antitrypsin in Liver Cirrhosis and
MA Comunale, L Rodemich-Betesh, J Hafner, M Wang… - 2010 - academia.edu
Background: We previously reported increased levels of protein-linked fucosylation with the
development of liver cancer and identified many of the proteins containing the altered glycan
structures. One such protein is alpha-1-antitrypsin (A1AT). To advance these studies, we
performed N-linked glycan analysis on the five major isoforms of A1AT and completed a
comprehensive study of the glycosylation of A1AT found in healthy controls, patients with
hepatitis C-(HCV) induced liver cirrhosis, and in patients infected with HCV with a diagnosis …
development of liver cancer and identified many of the proteins containing the altered glycan
structures. One such protein is alpha-1-antitrypsin (A1AT). To advance these studies, we
performed N-linked glycan analysis on the five major isoforms of A1AT and completed a
comprehensive study of the glycosylation of A1AT found in healthy controls, patients with
hepatitis C-(HCV) induced liver cirrhosis, and in patients infected with HCV with a diagnosis …
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