Linoleic acid and the regulation of glucose homeostasis: A review of the evidence
JS Hamilton, EL Klett - Prostaglandins, Leukotrienes and Essential Fatty …, 2021 - Elsevier
The consumption of linoleic acid (LA, ω-6 18: 2), the most common ω-6 polyunsaturated fatty
acid (PUFA) in the Modern Western diet (MWD), has significantly increased over the last
century in tandem with unprecedented incidence of chronic metabolic diseases like obesity
and type 2 diabetes mellitus (T2DM). Although an essential fatty acid for health, LA was a
very rare fatty acid in the diet of humans during their evolution. While the intake of other
dietary macronutrients (carbohydrates like fructose) has also risen, diets rich in ω-6 PUFAs …
acid (PUFA) in the Modern Western diet (MWD), has significantly increased over the last
century in tandem with unprecedented incidence of chronic metabolic diseases like obesity
and type 2 diabetes mellitus (T2DM). Although an essential fatty acid for health, LA was a
very rare fatty acid in the diet of humans during their evolution. While the intake of other
dietary macronutrients (carbohydrates like fructose) has also risen, diets rich in ω-6 PUFAs …
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