Lipid accumulation stimulates the cap-independent translation of SREBP-1a mRNA by promoting hnRNP A1 binding to its 5′-UTR in a cellular model of hepatic …
L Siculella, R Tocci, A Rochira, M Testini… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a chronic disease characterized by
accumulation of lipid droplets in hepatocytes. Enhanced release of non-esterified fatty acids
from adipose tissue accounts for a remarkable fraction of accumulated lipids. However, the
de novo lipogenesis (DNL) is also implicated in the etiology of the NAFLD. Sterol Regulatory
Element-Binding Protein-1 (SREBP-1) is a transcription factor modulating the expression of
several lipogenic enzymes. In the present study, in order to investigate the effect of lipid …
accumulation of lipid droplets in hepatocytes. Enhanced release of non-esterified fatty acids
from adipose tissue accounts for a remarkable fraction of accumulated lipids. However, the
de novo lipogenesis (DNL) is also implicated in the etiology of the NAFLD. Sterol Regulatory
Element-Binding Protein-1 (SREBP-1) is a transcription factor modulating the expression of
several lipogenic enzymes. In the present study, in order to investigate the effect of lipid …
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