[HTML][HTML] Lipoprotein lipase, a key role in atherosclerosis?
JR Mead, A Cryer, DP Ramji - FEBS letters, 1999 - Elsevier
JR Mead, A Cryer, DP Ramji
FEBS letters, 1999•ElsevierLipoprotein lipase (LPL) plays a central role in lipid metabolism and transport by catalysing
the hydrolysis of triacylglycerol-rich lipoproteins. The importance of LPL expressed by the
adipose tissue and muscles in the provision of non-esterified fatty acids and 2-
monoacylglycerol for tissue utilisation is well established. However, recent studies on LPL
expressed by cells of the vascular wall, particularly macrophages, have identified additional
actions of the enzyme that contribute to the promotion of foam cell formation and …
the hydrolysis of triacylglycerol-rich lipoproteins. The importance of LPL expressed by the
adipose tissue and muscles in the provision of non-esterified fatty acids and 2-
monoacylglycerol for tissue utilisation is well established. However, recent studies on LPL
expressed by cells of the vascular wall, particularly macrophages, have identified additional
actions of the enzyme that contribute to the promotion of foam cell formation and …
Lipoprotein lipase (LPL) plays a central role in lipid metabolism and transport by catalysing the hydrolysis of triacylglycerol-rich lipoproteins. The importance of LPL expressed by the adipose tissue and muscles in the provision of non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation is well established. However, recent studies on LPL expressed by cells of the vascular wall, particularly macrophages, have identified additional actions of the enzyme that contribute to the promotion of foam cell formation and atherosclerosis. This review deals with the role of LPL in atherosclerosis, and its regulation by mediators that are known to be present in the lesion.
Elsevier