In the search for inhibitorsof lipoxygenase (LOX) for therapeutic significance, this present study was aimed at evaluating the anti-lipoxygenase (anti-LOX) of the leaves of Ceiba pentandra-a Nigeria’s underutilized vegetable. This study tends to assess its antioxidant activity beside the antiinflammatory of the leaves through 2, 2′-azino-bis-(3-ethyl) benzothiazoline-6-sulfonic acid (ABTS) radical cation scavenging and anti-lypoxygenase (anti-LOX) activity tests. The positive control employed are indomethacin and ascorbic acid. The IC50 value for the anti-inflammatory activity of the extract is significant (102.5 µg/mL) when compared with that of the positive control 90.4 µg/mL (Indomethacin), the extract showed a good antioxidant effect with an IC50 of 0.99 µg/mL, ascorbic acid was used as a positive control (0.65 µg/mL). Hence, the results support the fact that many edible but neglected vegetables (the leaves of C. pentandra) in West Africa possess huge medicinal importance beside culinary uses.