Lead (Pb) is a chemical that belongs to the heavy metal group is bluish grey and is the main pollutants in the environment. The lead that enters the body will be distributed into the blood compound 95% and interfere with the body sistem, one of which is in the reproductive system. The purpose of writing this article is to determine the effects of lead toxicity on the reproductive system. The design of research used is the study of libraries from various sources. The articles are gathered using search engines such as PubMed, Google Schoolar, Science Direct, ProQuest and Elsevier. The article used in the study was published in 2011-2020. Based on the articles collected, it is derived that the consequences of exposure or lead poisoning are disruptive to the body sistem. Disrupted sistems include the reproductive sistem, digestive sistem, cardiovascular sistem and nervous sistem. Reproductive sistem disorders can occur in men and women. In men there can be decreased quality and quantity of sperm, decreased prostate function, decreased testosterone, decreased sexual desire. In women there can be decreased sexual desire, increased cases of infertility, spontaneous abortion, menstrual disorders and stillbirths. Lead poisoning in the reproductive sistem, disorders that can arise are decreased fertility in men and women, increased miscarriage, stillbirth, premature birth, and increased sex desire