Mental foramen (MF) is an important anatomic landmark in dentistry and knowledge about its variable locations (L) and type of emergence (TE), has an effect on the sufficiency of local anesthesia and safety of surgical procedures. The aim of this study was to evaluate the L and TE of this radiographic landmark as well as the presence of accessory MF, by means of cone-beam computed tomography (CBCT). In this cross sectional study, a total of 156 CBCT images were retrieved from the archive of a private radiology clinic and were then evaluated for the position of MF and its TE and the existence of accessory foramina in the body of mandible. The extracted information was compared in both genders, in both sides of mandible and among three different age groups (20-29, 30-44 and 45-59 years). The Pearson chi-square and Fisher’s Exact tests were used for statistical analysis. The level of significance was set at 0.05. Second premolar was the most common anterolateral L of MF; in general, 48.7% of right and 51.9% of left MFs were located at the apex of second premolar. Anterior and straight ET were more common in right and left side, respectively. Accessory MF was present in only 8 (5.1%) of cases. The possible presence of accessory MF should not be overlooked for avoiding the occurrence of a neurosensory disturbance during surgery and implant insertion.