Locomotor damage and brain oxidative stress induced by lead exposure are attenuated by gallic acid treatment
P Reckziegel, VT Dias, D Benvegnú, N Boufleur… - Toxicology letters, 2011 - Elsevier
We investigated the antioxidant potential of gallic acid (GA), a natural compound found in
vegetal sources, on the motor and oxidative damages induced by lead. Rats exposed to
lead (50 mg/kg, ip, once a day, 5 days) were treated with GA (13.5 mg/kg, po) or EDTA (110
mg/kg, ip) daily, for 3 days. Lead exposure decreased the locomotor and exploratory
activities, reduced blood ALA-D activity, and increased brain catalase (CAT) activity without
altering other antioxidant defenses. Brain oxidative stress (OS) estimated by lipid …
vegetal sources, on the motor and oxidative damages induced by lead. Rats exposed to
lead (50 mg/kg, ip, once a day, 5 days) were treated with GA (13.5 mg/kg, po) or EDTA (110
mg/kg, ip) daily, for 3 days. Lead exposure decreased the locomotor and exploratory
activities, reduced blood ALA-D activity, and increased brain catalase (CAT) activity without
altering other antioxidant defenses. Brain oxidative stress (OS) estimated by lipid …
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