Abnormally phosphorylated tau, an indicator of Alzheimer's disease, accumulates in the first
decades of life in the locus coeruleus (LC), the brain's main noradrenaline supply. However,
technical challenges in in-vivo assessments have impeded research into the role of the LC
in Alzheimer's disease. We studied participants with or known to be at-risk for mutations in
genes causing autosomal-dominant Alzheimer's disease (ADAD) with early onset, providing
a unique window into the pathogenesis of Alzheimer's largely disentangled from age-related …