Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7
Background—Heart transplantation is a lifesaving procedure for patients with end-stage
heart failure. Despite much effort and advances in the field, current immunosuppressive
regimens are still associated with poor long-term cardiac allograft outcomes, and with the
development of complications, including infections and malignancies, as well. The
development of a novel, short-term, and effective immunomodulatory protocol will thus be an
important achievement. The purine ATP, released during cell damage/activation, is sensed …
heart failure. Despite much effort and advances in the field, current immunosuppressive
regimens are still associated with poor long-term cardiac allograft outcomes, and with the
development of complications, including infections and malignancies, as well. The
development of a novel, short-term, and effective immunomodulatory protocol will thus be an
important achievement. The purine ATP, released during cell damage/activation, is sensed …
[PDF][PDF] Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7
P Fiorina - 2012 - academia.edu
Background—Heart transplantation is a lifesaving procedure for patients with end-stage
heart failure. Despite much effort and advances in the field, current immunosuppressive
regimens are still associated with poor long-term cardiac allograft outcomes as well as with
the development of complications including infections and malignancies. The development
of a novel, short-term and effective immunomodulatory protocol will thus be an important
achievement. The purine adenosine 5'-triphosphate (ATP), released during cell …
heart failure. Despite much effort and advances in the field, current immunosuppressive
regimens are still associated with poor long-term cardiac allograft outcomes as well as with
the development of complications including infections and malignancies. The development
of a novel, short-term and effective immunomodulatory protocol will thus be an important
achievement. The purine adenosine 5'-triphosphate (ATP), released during cell …
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