Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease
J Strobl, RV Pandey, T Krausgruber, N Bayer… - Science translational …, 2020 - science.org
The skin contains a population of tissue-resident memory T cells (Trm) that is thought to
contribute to local tissue homeostasis and protection against environmental injuries.
Although information about the regulation, survival program, and pathophysiological roles of
Trm has been obtained from murine studies, little is known about the biology of human
cutaneous Trm. Here, we showed that host-derived CD69+ αβ memory T cell clones in the
epidermis and dermis remain stable and functionally competent for at least 10 years in …
contribute to local tissue homeostasis and protection against environmental injuries.
Although information about the regulation, survival program, and pathophysiological roles of
Trm has been obtained from murine studies, little is known about the biology of human
cutaneous Trm. Here, we showed that host-derived CD69+ αβ memory T cell clones in the
epidermis and dermis remain stable and functionally competent for at least 10 years in …
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