Low population serum microneutralization antibody titer against the predominating influenza A (H3N2) N121K virus during the severe influenza summer peak of Hong …
Abstract The 2017 Hong Kong influenza A (H3N2) summer season was unexpectedly
severe. However, antigenic characterization of the 2017 circulating A (H3N2) viruses using
ferret antisera did not show significant antigenic drift. We analyzed the hemagglutinin amino
acid sequences of A (H3N2) virus circulating in Hong Kong in 2017, and found that viruses
with hemagglutinin N121K substitution, which was rare before 2017, emerged rapidly and
dominated in 2017 (52.4% of A [H3N2] virus in 2017 contains N121K substitution) …
severe. However, antigenic characterization of the 2017 circulating A (H3N2) viruses using
ferret antisera did not show significant antigenic drift. We analyzed the hemagglutinin amino
acid sequences of A (H3N2) virus circulating in Hong Kong in 2017, and found that viruses
with hemagglutinin N121K substitution, which was rare before 2017, emerged rapidly and
dominated in 2017 (52.4% of A [H3N2] virus in 2017 contains N121K substitution) …
Low population serum microneutralization antibody titer against the predominating influenza A (H3N2) N121K virus during the severe influenza summer peak of Hong …
ZHS Zhu HouShun, ACY Lee, LC Li Can, WWN Mak… - 2018 - cabidigitallibrary.org
Abstract The 2017 Hong Kong influenza A (H3N2) summer season was unexpectedly
severe. However, antigenic characterization of the 2017 circulating A (H3N2) viruses using
ferret antisera did not show significant antigenic drift. We analyzed the hemagglutinin amino
acid sequences of A (H3N2) virus circulating in Hong Kong in 2017, and found that viruses
with hemagglutinin N121K substitution, which was rare before 2017, emerged rapidly and
dominated in 2017 (52.4% of A [H3N2] virus in 2017 contains N121K substitution) …
severe. However, antigenic characterization of the 2017 circulating A (H3N2) viruses using
ferret antisera did not show significant antigenic drift. We analyzed the hemagglutinin amino
acid sequences of A (H3N2) virus circulating in Hong Kong in 2017, and found that viruses
with hemagglutinin N121K substitution, which was rare before 2017, emerged rapidly and
dominated in 2017 (52.4% of A [H3N2] virus in 2017 contains N121K substitution) …
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