… Mitogen-activated protein kinase (MAPK) modules containing three sequentially activated
protein kinases are key components of a series of vital signal transduction pathways that …

… Mitogen-activated protein kinase (MAPK) pathways regulate diverse processes ranging from
proliferation and differentiation to apoptosis. Activated by an enormous array of stimuli, they …

… Recent findings on these properties of MAP kinase cascades will be the major focus of
this review. Examples will be drawn from the ERK1/2 pathway as well as the other cascades. …

… MAP” from “microtubule-associated protein” to “mitogen-activated protein”, and thus the MAP
kinase … intense interest in the MAP kinase; a protein (Ser/Thr) kinase that was activated by …

… MAP kinases lie in protein kinase cascades. This review discusses the regulation and
functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase …

… substrates between pathways normally occurs. Assembly of kinase complexes and
discrimination of substrates provide the selectivity of sequential protein kinase pathways to regulate …

… kinase is upstream of MAP kinases and is either a MAP kinase kinase kinase or a MAP kinase
kinase kinase kinase… in the regulation of the MAP kinase pathway, then cells transformed …

… by upstream kinases referred to as MAP kinase kinase kinases (… stress-activated MAP kinase
pathways that have been … , MUK (MAPK upstream kinase), MLK (mixed lineage kinase), Tpl…

… The aberrations are pleiotropic, but mitogen-activated protein kinase (MAPK) pathways … on
the role of MAPK pathways in cancer. Cancerous mutations in MAPK pathways are frequently …

… the cellular context, Map kinase pathways can mediate signals … has established that Map
kinase pathways play critical roles in … , the involvement of various Map kinase pathways in the …