MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
K Krishnan, BYB Lau, G Ewall, ZJ Huang… - Nature …, 2017 - nature.com
Neurodevelopmental disorders are marked by inappropriate synaptic connectivity early in
life, but how disruption of experience-dependent plasticity contributes to cognitive and
behavioural decline in adulthood is unclear. Here we show that pup gathering behaviour
and associated auditory cortical plasticity are impaired in female Mecp2 het mice, a model of
Rett syndrome. In response to learned maternal experience, Mecp2 het females exhibited
transient changes to cortical inhibitory networks typically associated with limited plasticity …
life, but how disruption of experience-dependent plasticity contributes to cognitive and
behavioural decline in adulthood is unclear. Here we show that pup gathering behaviour
and associated auditory cortical plasticity are impaired in female Mecp2 het mice, a model of
Rett syndrome. In response to learned maternal experience, Mecp2 het females exhibited
transient changes to cortical inhibitory networks typically associated with limited plasticity …
[引用][C] MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice. Nat Commun 8: 14077
K Krishnan, BY Lau, G Ewall, ZJ Huang, SD Shea - 2017
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