MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca2+ Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi
The mitochondrial Ca2+ uptake in trypanosomatids, which belong to the eukaryotic
supergroup Excavata, shares biochemical characteristics with that of animals, which,
together with fungi, belong to the supergroup Opisthokonta. However, the composition of the
mitochondrial calcium uniporter (MCU) complex in trypanosomatids is quite peculiar,
suggesting lineage-specific adaptations. In this work, we used Trypanosoma cruzi to study
the role of orthologs for mitochondrial calcium uptake 1 (MICU1) and MICU2 in …
supergroup Excavata, shares biochemical characteristics with that of animals, which,
together with fungi, belong to the supergroup Opisthokonta. However, the composition of the
mitochondrial calcium uniporter (MCU) complex in trypanosomatids is quite peculiar,
suggesting lineage-specific adaptations. In this work, we used Trypanosoma cruzi to study
the role of orthologs for mitochondrial calcium uptake 1 (MICU1) and MICU2 in …
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