Macrophages are key cellular components of innate immunity, acting as the first line of
defense against pathogens to modulate homeostatic and inflammatory responses. They
help clear pathogens and shape the T-cell response through the production of cytokines and
chemokines. The facultative intracellular fungal pathogen Cryptococcus neoformans has
developed a unique ability to interact with and manipulate host macrophages. These
interactions dictate how Cryptococcus infection can remain latent or how dissemination …