Porphyromonas gingivalis is a primary etiological agent of chronic periodontal disease, an
infection-driven chronic inflammatory disease that leads to the resorption of tooth-supporting
alveolar bone. We previously reported that TLR2 is required for P. gingivalis–induced
alveolar bone loss in vivo, and our in vitro work implicated TNF as a key downstream
mediator. In this study, we show that TNF-deficient (Tnf−/−) mice are resistant to alveolar
bone loss following oral infection with P. gingivalis, and thus establish a central role for TNF …

Correction: Macrophage-Specific TLR2 Signaling Mediates Pathogen-Induced TNF-Dependent
Inflammatory Oral Bone Loss. - Abstract - Europe PMC … Correction: Macrophage-Specific
TLR2 Signaling Mediates Pathogen-Induced TNF-Dependent Inflammatory Oral Bone Loss. …