… of the mammalian circadian molecular clock, CLOCK and BMAL1, which belong to the family
of bHLH-PAS-containing transcription factors, constitute a positive feedback loop. CLOCK …

… Decs suppress the transactivation of Per gene by Clock/Bmal1, thus closing the loop. A
physiological role for Dec proteins in the molecular clock mechanism is supported by the timing …

… mammals. Inboth cases, molecular clock estimates give much older divergence dates
thanwould be expected from the fossil record (eg,Cooper & Fortey 1998,Bromham et al. 1999). …

… mammals have higher rates of nucleotide substitution, and in conclusion we note that a
molecular clock … the neutral theory than does a truly chronological clock. We note further that the …

… ratios between all possible pairs of these mammalian species. We have applied our model
… mammals at the third codon position as well. The divergence times for the four mammalian …

… generates clock oscillation. This brief review provides an update of results on the mechanisms
of clock oscillation and presents our view of molecular clock mechanisms in mammals. …

… is introduced for the calibration of molecular clocks and applied to the complete mitochondrial
… may desire a molecular clock specific to mammals, we performed analyses on mammals …

… date (the mammal–bird split) was directly used to calibrate the molecular clock. The second
calibration point (the primate–rodent split) was based on molecular estimates that were …

… Given that molecular clocks that coordinate such biological timing have evolved in almost …
in mammals and suggest the clock may be potential target for the treatment of disease. …

… Effect of CpG Dinucleotides on Hominoid Rate Slowdown and Mammalian Molecular
Clock Our findings shed important light on the controversy over mammalian molecular clock. …