The nuclear lamina is a proteinaceous network of filaments that provide both structural and
gene regulatory functions by tethering proteins and large domains of DNA, the so-called
lamina-associated domains (LADs), to the periphery of the nucleus. LADs are a large
fraction of the mammalian genome that are repressed, in part, by their association to the
nuclear periphery. The genesis and maintenance of LADs is poorly understood as are the
proteins that participate in these functions. In an effort to identify proteins that reside at the …

The nuclear lamina is a proteinaceous network of filaments that provide both structural and
gene regulatory functions by tethering proteins and large domains of DNA, so-called lamin
associated domains (LADs), to the periphery of the nucleus. LADs are a large fraction of the
mammalian genome that are repressed, in part, by their association to the nuclear periphery.
The genesis and maintenance of LADs is poorly understood as are the proteins that
participate in these functions. In an effort to identify proteins that reside at the nuclear …