Mast cells enhance proliferation of B lymphocytes and drive their differentiation toward IgA-secreting plasma cells
The evidence of a tight spatial interaction between mast cells (MCs) and B lymphocytes in
secondary lymphoid organs, along with the data regarding the abundance of MCs in several
B-cell lymphoproliferative disorders prompted us to investigate whether MCs could affect the
proliferation and differentiation of B cells. To this aim, we performed coculture assays using
mouse splenic B cells and bone marrow–derived MCs. Both nonsensitized and activated
MCs proved able to induce a significant inhibition of cell death and an increase in …
secondary lymphoid organs, along with the data regarding the abundance of MCs in several
B-cell lymphoproliferative disorders prompted us to investigate whether MCs could affect the
proliferation and differentiation of B cells. To this aim, we performed coculture assays using
mouse splenic B cells and bone marrow–derived MCs. Both nonsensitized and activated
MCs proved able to induce a significant inhibition of cell death and an increase in …
[引用][C] Mast cells enhance proliferation of B lymphocytes and drive their differentiation towards IgA-secreting plasma cells
Mast cells enhance proliferation of B lymphocytes and drive their differentiation towards IgA-secreting
plasma cells … Mast cells enhance proliferation of B lymphocytes and drive their
differentiation towards IgA-secreting plasma cells … Frossi B; Meluzzi S; Gri G; Parusso S;
Tripodo C; Pucillo C …
plasma cells … Mast cells enhance proliferation of B lymphocytes and drive their
differentiation towards IgA-secreting plasma cells … Frossi B; Meluzzi S; Gri G; Parusso S;
Tripodo C; Pucillo C …
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