[HTML][HTML] Matrix metalloproteinases-7 and kidney fibrosis
B Ke, C Fan, L Yang, X Fang - Frontiers in physiology, 2017 - frontiersin.org
B Ke, C Fan, L Yang, X Fang
Frontiers in physiology, 2017•frontiersin.orgMatrix metalloproteinase-7 (MMP-7) is a secreted zinc-and calcium-dependent
endopeptidase that degrades a broad range of extracellular matrix substrates and additional
substrates. MMP-7 playsa crucial role in a diverse array of cellular processes and appears to
be a key regulator of fibrosis in several diseases, including pulmonary fibrosis, liver fibrosis,
and cystic fibrosis. In particular, the relationship between MMP-7 and kidney fibrosis has
attracted significant attention in recent years. Growing evidence indicates that MMP-7 plays …
endopeptidase that degrades a broad range of extracellular matrix substrates and additional
substrates. MMP-7 playsa crucial role in a diverse array of cellular processes and appears to
be a key regulator of fibrosis in several diseases, including pulmonary fibrosis, liver fibrosis,
and cystic fibrosis. In particular, the relationship between MMP-7 and kidney fibrosis has
attracted significant attention in recent years. Growing evidence indicates that MMP-7 plays …
Matrix metalloproteinase-7 (MMP-7) is a secreted zinc- and calcium-dependent endopeptidase that degrades a broad range of extracellular matrix substrates and additional substrates. MMP-7 playsa crucial role in a diverse array of cellular processes and appears to be a key regulator of fibrosis in several diseases, including pulmonary fibrosis, liver fibrosis, and cystic fibrosis. In particular, the relationship between MMP-7 and kidney fibrosis has attracted significant attention in recent years. Growing evidence indicates that MMP-7 plays an important role in the pathogenesis of kidney fibrosis. Here, we summarize the recent progress in the understanding of the role of MMP-7 in kidney fibrosis. In particular, we discuss how MMP-7 contributes to kidney fibrotic lesions via the following three pathways: epithelial-mesenchymal transition (EMT), transforming growth factor-beta (TGF-β) signaling, and extracellular matrix (ECM) deposition. Further dissection of the crosstalk among and regulation of these pathways will help clinicians and researchers develop effective therapeutic approaches for treating chronic kidney disease.
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