… -C7, and C4-C8 for Pi1 or HsTx1, two MTX-related scorpion toxins)… from the MTX toward the
Pi1/HsTx1 disulfide bridge pattern. … maurotoxin analogue with α-amino butyrate derivatives in …

… ); MTX Pi1 , synthetic maurotoxin with imposed standard (Pi1-… , reduced or oxidized form of
synthetic maurotoxin with a 2,6 … ; HsTx1, toxin 1 from the scorpion Heterometrus spinnifer; Pi1, …

… mean square derivative of the energy function was less than 0.001 kcal/mol. … Pi1 or HsTx1,
two related toxins. This pattern is therefore referred to as the Pi1/HsTx1 pattern or MTX Pi1 …

… Pi1 resembles mostly to those of maurotoxin and HsTx1, two other scorpion toxins cross-linked
by four disulfide bridges. Also, Pi1 … both HsTx1 and maurotoxin. The main differences with …

… HsTx1, Pi1 and Pi4, we expected that structural variations induced by the mutagenesis of these
proline residues could favor the shift from a MTX-like to a Pi1/HsTx1-… -square derivative of …

… Pandinus imperator toxin1 (Pi1) and maurotoxin, two recently … We have determined the
complete primary structure of HsTX1… of the reduced and pyridylethylated derivative, in a single run…

… Pi1 and HsTx1), two novel four-disulfide bridged K + channel-acting scorpion toxin sharing
about 50–70% sequence identity with maurotoxin… Results showed that no PTH derivative was …

… channels ~maurotoxin!. If the pairing of the six cysteines conserved in all scorpion … in
maurotoxin, it is conserved in Pi1 and HsTX1. Moreover, the overall fold of maurotoxin and Pi1 is …

… Pi1, Pi4, Pi7, and HsTx1, four toxins belonging to the same α-KTx6 family. 33 This MTX variant,
termed MTX Pi1 … 6 In the following sections, we will refer to MTX Pi1 instead of MTX since, …

… Together with maurotoxin, Pi1, Pi7 and HsTx1, Pi4 belongs to the α KTX6 subfamily of short
… a conventional pattern of scorpion toxin reticulation (Pi1/HsTx1 type). In vivo, sPi4 was lethal …