Mechanism of transient adsorption of fibrinogen from plasma to solid surfaces: role of the contact and fibrinolytic systems

JL Brash, CF Scott, P ten Hove, P Wojciechowski… - 1988 - ashpublications.org
The transient detection of fibrinogen on surfaces has been described (Vroman effect) and
high-mol-wt kininogen (HK) has been shown to play a role in this reaction. In this study, we
attempted to identify the form of HK responsible for preventing detection of the fibrinogen
initially adsorbed from plasma to various artificial surfaces and to determine if other plasma
components were involved. We compared 125I-fibrinogen adsorption in the presence of
normal plasma to plasma deficient in specific proteins. On all surfaces tested, we found that …

[PDF][PDF] Mechanism of transient adsorption of fibrinogen from plasma to solid

JL Brash, CF Scott, P ten Hove, P Wojciechowski… - 2011 - researchgate.net
The transient detection of fibrinogen on surfaces has been described(Vroman effect) and
high-mol-wt kininogen(HK) has been shown to play a role in this reaction. In this study. we
attempted to identify the form of HK responsible for preventing detection of the fibrinogen
initially adsorbed from plasma to various artificial surfaces and to determine if other plasma
components were involved. We compared 125l-fibrinogen adsorption in the presence of
normal plasma to plasma deficient in specific proteins. On all surfaces tested. we found that …
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