Individuals with ESKD requiring maintenance hemodialysis face a unique hemodynamic
challenge, typically on a thrice-weekly basis. In an effort to achieve some degree of
euvolemia, ultrafiltration goals often involve removal of the equivalent of an entire plasma
volume. Maintenance of adequate end-organ perfusion in this setting is dependent on the
institution of a variety of complex compensatory mechanisms. Unfortunately, secondary to a
myriad of patient-and dialysis-related factors, this compensation often falls short and results …