Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells
M Esen, B Schreiner, V Jendrossek, F Lang… - Apoptosis, 2001 - Springer
M Esen, B Schreiner, V Jendrossek, F Lang, K Fassbender, H Grassme, E Gulbins
Apoptosis, 2001•SpringerStaphylococcus aureus plays an important role in sepsis, pneumonia and wound infections.
Here, we demonstrate that infection with several S. aureus strains results in apoptosis of
human endothelial cells. S. aureus induced an activation of cellular caspases, the acid
sphingomyelinase, a release of cytochrome c and a stimulation of Jun NH 2-terminal kinase
(JNK). The significance of these findings is indicated by a prevention of S. aureus triggered
apoptosis of human cells deficient for ASM or upon genetic or pharmacological inhibition of …
Here, we demonstrate that infection with several S. aureus strains results in apoptosis of
human endothelial cells. S. aureus induced an activation of cellular caspases, the acid
sphingomyelinase, a release of cytochrome c and a stimulation of Jun NH 2-terminal kinase
(JNK). The significance of these findings is indicated by a prevention of S. aureus triggered
apoptosis of human cells deficient for ASM or upon genetic or pharmacological inhibition of …
Abstract
Staphylococcus aureus plays an important role in sepsis, pneumonia and wound infections. Here, we demonstrate that infection with several S. aureus strains results in apoptosis of human endothelial cells. S. aureus induced an activation of cellular caspases, the acid sphingomyelinase, a release of cytochrome c and a stimulation of Jun NH2-terminal kinase (JNK). The significance of these findings is indicated by a prevention of S. aureus triggered apoptosis of human cells deficient for ASM or upon genetic or pharmacological inhibition of JNK or caspases, respectively.
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